HCID 21951129、化合物 → N1-(2-Hydroxyethyl)-2-methyl-1,2-propanediamine
反応式
[CH3:1][C:2]([N+:9]([O-])=O)([CH3:8])[CH2:3][NH:4][CH2:5][CH2:6][OH:7]>CO.[Ni].O>[NH2:9][C:2]([CH3:8])([CH3:1])[CH2:3][NH:4][CH2:5][CH2:6][OH:7]参加物
5
実験手順
To a solution of 2-((2-methyl-2-nitropropyl)amino)ethanol (9.7 g, 60 mmol) in Methanol (65 ml) was added a slurry of 50% Raney Nickel® in H2O (3 ml). The vessel was pressurized with H2 (450 psi) and the suspension stirred for 48 h. The mixture was filtered through Celite® and concentrated in vacuo to give 7.4 g of a crude liquid, which was used directly in the next step without purification. LRMS (ESI/APCI) m/z 133 [M+H]+.
後処理
- filtrationThe mixture was filtered through Celite®
- concentrationconcentrated in vacuo
出典と根拠
- ORDレコード
- ord-b59e350e35a446208ddf91bc5d85f049
- 出典データセット
- uspto-grants-2016_02
- 特許番号
- US09248117B2
反応ノート
読み込み中…