Sodium Methoxide → HCID 57562885、化合物

反応式

[NH2:1][S:2]([C:5]1[CH:6]=[C:7]([N+:13]([O-:15])=[O:14])[CH:8]=[C:9]([CH3:12])[C:10]=1F)(=[O:4])=[O:3].[CH3:16][O-:17].[Na+]>>[NH2:1][S:2]([C:5]1[CH:6]=[C:7]([N+:13]([O-:15])=[O:14])[CH:8]=[C:9]([CH3:12])[C:10]=1[O:17][CH3:16])(=[O:4])=[O:3]

参加物

反応物 2

HCID 10942334Sodium Methoxide

HCID 57562895HCID 57562895、化合物

生成物 1

HCID 57562885HCID 57562885、化合物

実験手順

The resulting 3-aminosulfonyl-4-fluoro-5-methylnitrobenzene (0.940 g, 4 mmol) was stirred with 25% methanolic NaOMe (1.00 mL) at 60° C. for overnight. The resulting solution was then filtered through a pad of Celite, washed with methanol and the methanolic solution was concentrated to give 3-aminosulfonyl-4-methoxy-5-methylnitrobenzene. LCMS: purity: 100%, MS (m/e): 247 (MH+).

後処理

filtrationThe resulting solution was then filtered through a pad of Celite
washwashed with methanol
concentrationthe methanolic solution was concentrated

出典と根拠

ORDレコード: ord-e6028c0ee2334fc8820b27a5bdfab4d4
出典データセット: uspto-grants-2016_02
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US09248190B2

反応ノート

読み込み中…

参加物