Hydrochloric Acid → Tapentadol Hydrochloride
反応式
[ClH:1].[CH2:2]([C@@H:4]([C:11]1[CH:16]=[CH:15][CH:14]=[C:13]([O:17]CC2C=CC=CC=2)[CH:12]=1)[C@@H:5]([CH3:10])[CH2:6][N:7]([CH3:9])[CH3:8])[CH3:3]>O>[ClH:1].[CH3:9][N:7]([CH3:8])[CH2:6][C@H:5]([CH3:10])[C@H:4]([C:11]1[CH:12]=[C:13]([OH:17])[CH:14]=[CH:15][CH:16]=1)[CH2:2][CH3:3]参加物
4
実験手順
20 mL of water and 20 mL of concentrated hydrochloric acid were added to the product of Example 38 (2.5 g, 8 mmol), then it was reacted at 80° C. for 17 hours, after that, the reaction solution was concentrated and recrystallized with isopropanol and isopropyl ether to give the target 1.9 g, yield: 90%. The HNMR spectrum data is the same as that in Example 7.
後処理
- customit was reacted at 80° C. for 17 hours
- concentrationafter that, the reaction solution was concentrated
- customrecrystallized with isopropanol and isopropyl ether
- customto give the target 1.9 g, yield: 90%
出典と根拠
- ORDレコード
- ord-ae3605cf9a9b400aaff0c19b92126691
- 出典データセット
- uspto-grants-2016_02
- 特許番号
- US09249084B2
反応ノート
読み込み中…