Methanol → Methyl (R)-3-[(benzyloxycarbonyl)amino]-4-hydroxybutanoate

HRID 1771160

反応式

HRID 1771160 の反応式
[O:1]=[C:2]1[O:6][CH2:5][C@H:4]([NH:7][C:8](=[O:17])[O:9][CH2:10][C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[CH2:3]1.C(N(CC)CC)C.[CH3:25][OH:26]>>[CH2:10]([O:9][C:8]([NH:7][C@@H:4]([CH2:25][OH:26])[CH2:3][C:2]([O:6][CH3:5])=[O:1])=[O:17])[C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1

参加物

4

反応物 3

HCID 887MethanolHCID 8471TriethylamineHCID 697924(R)-Benzyl (5-oxotetrahydrofuran-3-yl)carbamate2 回

生成物 1

HCID 59108917Methyl (R)-3-[(benzyloxycarbonyl)amino]-4-hydroxybutanoate

実験手順

(R)-Benzyl 5-oxotetrahydrofuran-3-ylcarbamate (INTERMEDIATE 3, 27.0 g, 114.78 mmol) was dissolved in methanol (75 ml) and triethylamine (75 ml) was added at room temperature. The resulting mixture was allowed to stir overnight at this temperature. The mixture was concentrated in vacuo to provide the title product. This material was used to prepare INTERMEDIATE 5 without further purification.

後処理

  1. concentrationThe mixture was concentrated in vacuo

出典と根拠

ORDレコード
ord-79bedf261bf8412f87aa039514b9c9ac
出典データセット
uspto-grants-2016_02
特許番号
US09248140B2

関連ノート

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