4-Fluorophenylglyoxal hydrate → 5-(4-Fluoro-phenyl)-3-methylsulfanyl-[1,2,4]triazine

反応式

[NH:1]([C:3]([S:5][CH3:6])=[NH:4])[NH2:2].O.[F:8][C:9]1[CH:14]=[CH:13][C:12]([C:15]([CH:17]=O)=O)=[CH:11][CH:10]=1>>[CH3:6][S:5][C:3]1[N:1]=[N:2][CH:17]=[C:15]([C:12]2[CH:13]=[CH:14][C:9]([F:8])=[CH:10][CH:11]=2)[N:4]=1

参加物

反応物 2

HCID 27374704-Fluorophenylglyoxal hydrate

HCID 178504051Methyl hydrazinecarbimidothioate

生成物 1

HCID 6542465-(4-Fluoro-phenyl)-3-methylsulfanyl-[1,2,4]triazine収率 69%

実験手順

3-(Methylsulfanyl)-5-(4-fluorophenyl)-1,2,4-triazine (6.00 g, 69%) was prepared from methyl hydrazinecarbimidothioate (4.51 g, 43.0 mmol) and 4-fluorophenylglyoxal monohydrate (6.60 g, 43.0 mmol) according to the general procedure of Preparation 2.

後処理

customaccording to the general procedure of Preparation 2

出典と根拠

ORDレコード: ord-c5f953ae782c4214968f1707bf7ab0f4
出典データセット: uspto-grants-2016_02
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US09249130B2

反応ノート

読み込み中…