HCID 71766904、化合物 → HCID 71766907、化合物
反応式
Cl[C:2]1[CH:11]=[CH:10][CH:9]=[C:8]2[C:3]=1[CH2:4][CH2:5][O:6][CH:7]2[C:12]1[NH:13][CH2:14][CH2:15][N:16]=1.[C:17]([Zn]C#N)#[N:18]>CC(C)([P](C(C)(C)C)([Pd][P](C(C)(C)C)(C(C)(C)C)C(C)(C)C)C(C)(C)C)C.CN(C=O)C>[NH:13]1[CH2:14][CH2:15][N:16]=[C:12]1[CH:7]1[C:8]2[CH:9]=[CH:10][CH:11]=[C:2]([C:17]#[N:18])[C:3]=2[CH2:4][CH2:5][O:6]1参加物
5
反応条件
- 温度
- 160 °C
実験手順
A mixture of 2-(5-chloroisochroman-1-yl)-4,5-dihydro-1H-imidazole (50 mg), dicyanozinc (25 mg), bis(tri-t-butylphosphine)palladium(0) (3 mg) and DMF (2 ml) was stirred in microwave reactor at 160° C. for 30 minutes. The title compound was purified with separation methods F and G. (Yield 22 mg).
後処理
- customThe title compound was purified with separation methods F and G
出典と根拠
- ORDレコード
- ord-cc1510cec0f14b289b154a84fc77cdcd
- 出典データセット
- uspto-grants-2016_02
- 特許番号
- US09249127B2
反応ノート
読み込み中…