1-(Tributylstannyl)methanol → (1-(4,5-Dihydro-1H-imidazol-2-yl)isochroman-5-yl)methanol

HRID 1771413ノート

反応式

HRID 1771413 の反応式
Br[C:2]1[CH:11]=[CH:10][CH:9]=[C:8]2[C:3]=1[CH2:4][CH2:5][O:6][CH:7]2[C:12]1[NH:13][CH2:14][CH2:15][N:16]=1.C([Sn]([CH2:30][OH:31])(CCCC)CCCC)CCC>>[NH:13]1[CH2:14][CH2:15][N:16]=[C:12]1[CH:7]1[C:8]2[C:3](=[C:2]([CH2:30][OH:31])[CH:11]=[CH:10][CH:9]=2)[CH2:4][CH2:5][O:6]1

参加物

3

反応物 2

HCID 41935931-(Tributylstannyl)methanolHCID 717669082-(5-bromoisochroman-1-yl)-4,5-dihydro-1H-imidazole

生成物 1

HCID 71767060(1-(4,5-Dihydro-1H-imidazol-2-yl)isochroman-5-yl)methanol

実験手順

The title compound was prepared from 2-(5-bromoisochroman-1-yl)-4,5-dihydro-1H-imidazole (50 mg) and (tributylstannyl)methanol (86 mg) by using tetrakis(triphenyl-phosphine)palladium (10.28 mg) as catalyst, and the procedure of synthesis method C and separation methods F and G. (Yield 6.2 mg).

後処理

  1. customthe procedure of synthesis method C and separation methods F and G

出典と根拠

ORDレコード
ord-ceaa6c2a00dd4123ab46110c52170bf6
出典データセット
uspto-grants-2016_02
特許番号
US09249127B2

反応ノート

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