Water → 4-(4-Bromophenyl)-6,7-dimethoxy-2-naphthol

HRID 1771515ノート

反応式

HRID 1771515 の反応式
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C:8](=O)[CH2:9][C:10](=[O:22])[CH2:11][C:12]2[CH:17]=[CH:16][C:15]([O:18][CH3:19])=[C:14]([O:20][CH3:21])[CH:13]=2)=[CH:4][CH:3]=1.O>P(=O)(O)(O)O>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[C:17]3[C:12](=[CH:13][C:14]([O:20][CH3:21])=[C:15]([O:18][CH3:19])[CH:16]=3)[CH:11]=[C:10]([OH:22])[CH:9]=2)=[CH:4][CH:3]=1

参加物

4

反応物 2

HCID 962WaterHCID 591887201-(4-Bromophenyl)-4-(3,4-dimethoxyphenyl)butane-1,3-dione

生成物 1

HCID 591887014-(4-Bromophenyl)-6,7-dimethoxy-2-naphthol収率 90%

試薬・触媒・溶媒 1

HCID 1004Phosphoric Acid溶媒

実験手順

1-(4-Bromophenyl)-4-(3,4-dimethoxyphenyl)butane-1,3-dione (3 g, 8 mmol) in 85% phosphoric acid was heated at 70° C. for 20 h. The resulting solution was cooled, poured into water (150 ml) and filtered. The residue was dissolved in dichloromethane (50 ml), washed with water (50 ml), dried (MgSO4) and the solvent was removed under reduced pressure to give the title compound (2.56 g, 90%) as a brown powder.

後処理

  1. temperatureThe resulting solution was cooled
  2. filtrationfiltered
  3. dissolutionThe residue was dissolved in dichloromethane (50 ml)
  4. washwashed with water (50 ml)
  5. dry with materialdried (MgSO4)
  6. customthe solvent was removed under reduced pressure

出典と根拠

ORDレコード
ord-c2da843f6db24b4d942af4ae76a03635
出典データセット
uspto-grants-2016_02
特許番号
US09249136B2

反応ノート

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