Water → 5-Bromo-2-hydroxy-3-methylbenzoic acid

HRID 1771692

反応式

HRID 1771692 の反応式
[OH:1][C:2]1[C:10]([CH3:11])=[CH:9][CH:8]=[CH:7][C:3]=1[C:4]([OH:6])=[O:5].[Br:12]Br.O>C(O)(=O)C>[Br:12][C:8]1[CH:9]=[C:10]([CH3:11])[C:2]([OH:1])=[C:3]([CH:7]=1)[C:4]([OH:6])=[O:5]

参加物

5

反応物 3

HCID 962WaterHCID 67383-Methylsalicylic AcidHCID 24408Bromine

生成物 1

HCID 27643455-Bromo-2-hydroxy-3-methylbenzoic acid収率 90%

試薬・触媒・溶媒 1

HCID 176Acetic Acid溶媒

実験手順

To a solution of 2-hydroxy-3-methyl-benzoic acid (10 g, 66.7 mmol, 1.0 eq) in acetic acid (100 mL) was added bromine (10.66 g, 66.7 mmol, 1.0 eq) slowly over 5 min. The mixture was stirred at room temperature for 24 h, then water was added slowly and the mixture was stirred for a further 30 min. The precipitate was collected by filtration and was washed with water and dried to give the title compound as a white solid (13.7 g, 90%).

後処理

  1. stirringthe mixture was stirred for a further 30 min
  2. filtrationThe precipitate was collected by filtration
  3. washwas washed with water
  4. customdried

出典と根拠

ORDレコード
ord-b149146ff32147459cb49995c534d411
出典データセット
uspto-grants-2016_02
特許番号
US09249085B2

関連ノート

読み込み中…