4-Bromoisoindolin-1-one → 4-[5-[3-Chloro-5-(trifluoromethoxy)phenyl]-1-(3-pyridyl)pyrazol-3-yl]isoindolin-1-one

HRID 1771916ノート

反応式

HRID 1771916 の反応式
[Cl:1][C:2]1[CH:3]=[C:4]([C:13]2[N:17]([C:18]3[CH:19]=[N:20][CH:21]=[CH:22][CH:23]=3)[N:16]=[C:15]([C:24]3[C:29]4[CH2:30][NH:31][C:32](=[O:33])[C:28]=4[CH:27]=[CH:26]N=3)[CH:14]=2)[CH:5]=[C:6]([O:8][C:9]([F:12])([F:11])[F:10])[CH:7]=1.Cl[C:35]1C2CNC(=O)C=2C=CN=1.BrC1C=CC=C2C=1CNC2=O>>[Cl:1][C:2]1[CH:3]=[C:4]([C:13]2[N:17]([C:18]3[CH:19]=[N:20][CH:21]=[CH:22][CH:23]=3)[N:16]=[C:15]([C:24]3[CH:35]=[CH:26][CH:27]=[C:28]4[C:29]=3[CH2:30][NH:31][C:32]4=[O:33])[CH:14]=2)[CH:5]=[C:6]([O:8][C:9]([F:11])([F:12])[F:10])[CH:7]=1

参加物

4

反応物 3

HCID 219075094-Bromoisoindolin-1-oneHCID 733352174-[5-[3-Chloro-5-(trifluoromethoxy)phenyl]-1-(3-pyridyl)pyrazol-3-yl]-2,3-dihydropyrrolo[3,4-c]pyridin-1-one2 回HCID 825978324-chloro-1H,2H,3H-pyrrolo[3,4-c]pyridin-1-one

生成物 1

HCID 733352184-[5-[3-Chloro-5-(trifluoromethoxy)phenyl]-1-(3-pyridyl)pyrazol-3-yl]isoindolin-1-one

実験手順

The synthesis of the title compound is performed starting from 100 mg (0.24 mmol) of the product from step 3 of the compound from example 10 in a manner analogous to step 4 of the synthesis of the compound from example 10. Instead of the compound from example 22A, 4-bromo-2,3-dihydroisoindole-1-on (61 mg, 0.29 mmol) is used. This produces 28 mg (24% of theoretical yield, 94% purity) of the title compound.

出典と根拠

ORDレコード
ord-421a88d15c7348a382ee262548c11655
出典データセット
uspto-grants-2016_02
特許番号
US09249148B2

反応ノート

読み込み中…