Hydrochloric Acid → (3S)-piperidine-3-carboxylic acid hydrochloride
反応式
C(OC([N:8]1[CH2:13][CH2:12][CH2:11][C@H:10]([C:14]([OH:16])=[O:15])[CH2:9]1)=O)(C)(C)C.[ClH:17]>C(O)(=O)C>[ClH:17].[NH:8]1[CH2:13][CH2:12][CH2:11][C@H:10]([C:14]([OH:16])=[O:15])[CH2:9]1参加物
4
反応条件
- 温度
- 15 °C
実験手順
(S)-Piperidine-1,3-dicarboxylic acid 1-tert-butyl ester (20 kg, 87.2 mol) was slurried in acetic acid (189 kg) and cooled to 15° C. An excess of hydrogen chloride gas (9.6 kg) was charged and stirred for ˜4 hours to complete deprotection. The slurry was isolated and filter-cake rinsed with acetic acid (2×31.5 kg). The filter cake was then vacuum dried to obtain product (14.4 kg).
後処理
- customThe slurry was isolated
- filtrationfilter-cake
- washrinsed with acetic acid (2×31.5 kg)
- customvacuum dried
出典と根拠
- ORDレコード
- ord-925b7b092fbe451aa4d191be1ffa875b
- 出典データセット
- uspto-grants-2016_02
- 特許番号
- US09249155B2
反応ノート
読み込み中…