関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | N,N-Dimethylaniline | HCID 949 | — |
| 反応物 | 2,5-Dimethylpyrazine | HCID 31252 | — |
| 生成物 | 3,6-Dimethylpyrazin-2-amine | HCID 13261500 | 10% |
反応手順
A mixture of 2,5-dimethylpyrazine (14 g, 0.13 mol) in N,N-dimethylaniline (50 mL) was heated to 170° C. and NaNH2 (22 g, 0.56 mol) was added in portions. The reaction mixture was stirred at 170° C. for 1 h, and the solvent was removed. The product was purified by silica gel column chromatography to give 3,6-dimethylpyrazin-2-amine as a brown solid (1.6 g, yield 10%). ESI MS: m/z 124 [M+H]+.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US09249162B2 |
|---|
| 出典データセット | uspto-grants-2016_02 |
|---|
| ORD ID | ord-9de2d6ac326c466ba5d1bcbc64d40b01 |
|---|
| 出典メモ | uspto-grants-2016_02 |
|---|
