Imidazo[1,2-a]pyridin-2-ylmethanol → Imidazo(1,2-a)pyridine-2-carbaldehyde
反応式
[N:1]1[C:2]([CH2:10][OH:11])=[CH:3][N:4]2[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=12>CCO.[O-2].[Mn+4].[O-2]>[NH3:1].[OH2:11].[N:1]1[C:2]([CH:10]=[O:11])=[CH:3][N:4]2[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=12参加物
5
実験手順
To a solution of imidazo[1,2-a]pyridin-2-ylmethanol (3.0 g, 20 mmol) in EtOH (50 mL) was added manganese (IV) oxide (8.8 g, 100 mmol). The mixture was refluxed for 2 days. After cooling to room temperature, the mixture was filtered through Celite, and the filtrate was concentrated. The residue was purified by reverse phase column chromatography (eluting with acetonitrile in water 25% v/v, with 0.01% NH3.H2O) to afford the title compound (0.45 g, 15% yield) as a yellow solid. ESI MS: m/z 147 [M+H]+.
後処理
- temperatureThe mixture was refluxed for 2 days
- filtrationthe mixture was filtered through Celite
- concentrationthe filtrate was concentrated
- customThe residue was purified by reverse phase column chromatography (
- washeluting with acetonitrile in water 25% v/v
出典と根拠
- ORDレコード
- ord-f1a56ae2a061441bbe4589d52fdcfbbb
- 出典データセット
- uspto-grants-2016_02
- 特許番号
- US09249162B2
反応ノート
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