Ethanol → HCID 89482605、化合物

反応式

[CH3:1][N:2]1[C:6]([NH2:7])=[CH:5][C:4]([CH:8]2[CH2:13][CH2:12][CH2:11][CH2:10][NH:9]2)=[N:3]1.[CH:14]([O:16][CH2:17][C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1)=[O:15].C(O)C.C1(=O)CCCCC1>C(OCC)(=O)C>[CH3:1][N:2]1[C:6]([NH2:7])=[C:5]([C:18]2[CH2:23][CH2:22][CH2:21][CH2:20][CH:19]=2)[C:4]([CH:8]2[CH2:13][CH2:12][CH2:11][CH2:10][NH:9]2)=[N:3]1.[CH:14]([O:16][CH2:17][C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1)=[O:15]

参加物

実験手順

Under nitrogen atmosphere, to a 250 mL three-neck reaction flask were added the compound of Example 11B (11.7 g, 37 mmol), ethanol (150 mL) and cyclohexanone (15.5 mL, 149 mmol). The mixture reacted overnight at 50° C. to 60° C. After cooled to room temperature, acetic acid was removed by rotary-evaporation to obtain a crude product. The crude product was subject to column chromatography (eluant: petroleum ether:ethyl acetate=2:1) to give 8.0 g of the title compound. Yield: 54.4%. MS (ESI): m/z 395 (M+H)+