2-Amino-4'-chlorobenzophenone → 5-(4-Chlorophenyl)spiro[benzo[e][1,4]diazepine-3,1'-cyclopropan]-2(1H)-one
反応式
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[C:14]3[C:15]([CH3:19])=C(C)S[C:13]=3[N:12]3C(C)=NN=[C:11]3[C:10]([CH3:25])([CH3:24])[N:9]=2)=[CH:4][CH:3]=1.N[C:27]1C=CC=C[C:28]=1C(C1C=CC(Cl)=CC=1)=O.NC1SC(C)=C(C)C=1C(C1C=CC(Cl)=CC=1)=[O:49]>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[C:14]3[CH:15]=[CH:19][CH:28]=[CH:27][C:13]=3[NH:12][C:11](=[O:49])[C:10]3([N:9]=2)[CH2:24][CH2:25]3)=[CH:6][CH:7]=1参加物
4
反応物 3
生成物 1
実験手順
A procedure analogous to that set forth in the synthesis of Compound 214 was followed, with the exception that (2-aminophenyl)(4-chlorophenyl)methanone was used as starting material instead of (2-amino-4,5-dimethylthiophen-3-yl)(4-chlorophenyl)methanone. LRMS (M+H)+: 297 m/z.