3,3-Difluoro-5-(8-morpholino-2-(2-(quinolin-2-yl)ethyl)imidazo[1,2-a]pyrazin-5-yl)indolin-2-one → Potassium 3,3-difluoro-5-(8-morpholino-2-(2-(quinolin-2-yl)ethyl)imidazo[1,2-a]pyrazin-5-yl)-2-oxoindolin-1-ide

HRID 1772667ノート

反応式

HRID 1772667 の反応式
[F:1][C:2]1([F:39])[C:10]2[C:5](=[CH:6][CH:7]=[C:8]([C:11]3[N:16]4[CH:17]=[C:18]([CH2:20][CH2:21][C:22]5[CH:31]=[CH:30][C:29]6[C:24](=[CH:25][CH:26]=[CH:27][CH:28]=6)[N:23]=5)[N:19]=[C:15]4[C:14]([N:32]4[CH2:37][CH2:36][O:35][CH2:34][CH2:33]4)=[N:13][CH:12]=3)[CH:9]=2)[NH:4][C:3]1=[O:38].O(C)[K:41]>CO>[F:39][C:2]1([F:1])[C:10]2[C:5](=[CH:6][CH:7]=[C:8]([C:11]3[N:16]4[CH:17]=[C:18]([CH2:20][CH2:21][C:22]5[CH:31]=[CH:30][C:29]6[C:24](=[CH:25][CH:26]=[CH:27][CH:28]=6)[N:23]=5)[N:19]=[C:15]4[C:14]([N:32]4[CH2:33][CH2:34][O:35][CH2:36][CH2:37]4)=[N:13][CH:12]=3)[CH:9]=2)[N-:4][C:3]1=[O:38].[K+:41]

参加物

4

反応物 2

HCID 863456813,3-Difluoro-5-(8-morpholino-2-(2-(quinolin-2-yl)ethyl)imidazo[1,2-a]pyrazin-5-yl)indolin-2-oneHCID 178502595HCID 178502595、化合物

生成物 1

HCID 123133231Potassium 3,3-difluoro-5-(8-morpholino-2-(2-(quinolin-2-yl)ethyl)imidazo[1,2-a]pyrazin-5-yl)-2-oxoindolin-1-ide

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

反応条件

温度
0 °C

実験手順

Compound 37c (65.3 mg, 0.124 mmol) was added to a MeOH solution of KOMe (8.69 mg, 0.124 mmol) at 0° C. The resulting mixture was stirred at 0° C. for 15 min, allowed to warm to rt, and stirred for another 30 min. The resulting mixture was concentrated and the resulting residue was dried under reduced pressure to obtain the title compound 59. 1H-NMR (400 MHz, DMSO-d6) δ (ppm): 8.25 (d, J=8.6 Hz, 1H), 7.92 (d, J=8.3 Hz, 2H), 7.71 (t, J=7.7 Hz, 1H), 7.45-7.59 (m, 4H), 7.40 (br. s., 1H), 7.26 (s, 1H), 6.84 (d, J=7.6 Hz, 1H), 4.06 (m, 4H), 3.68 (m, 4H) 3.27-3.35 (m, 2H), 3.19-3.27 (m, 2H). Mass Spectrum (LCMS, ESI pos.) Calcd. For C29H24F2N6O2: 527.2 (M+H). Found 527.5.

後処理

  1. temperatureto warm to rt
  2. stirringstirred for another 30 min
  3. concentrationThe resulting mixture was concentrated
  4. customthe resulting residue was dried under reduced pressure

出典と根拠

ORDレコード
ord-5b33b9fcad724849bc97260239410c45
出典データセット
uspto-grants-2016_02
特許番号
US09249163B2

反応ノート

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