Ammonium Hydroxide → 6-Bromo-3-chloropyrazin-2-amine

HRID 1772747

反応式

HRID 1772747 の反応式
Br[C:2]1[C:3]([Cl:9])=[N:4][CH:5]=[C:6]([Br:8])[N:7]=1.[NH4+:10].[OH-]>>[Br:8][C:6]1[N:7]=[C:2]([NH2:10])[C:3]([Cl:9])=[N:4][CH:5]=1

参加物

3

反応物 2

HCID 14923Ammonium HydroxideHCID 533503583,5-Dibromo-2-chloropyrazine

生成物 1

HCID 569657236-Bromo-3-chloropyrazin-2-amine収率 66%

反応条件

温度
100 °C

実験手順

Into a 250 mL sealed tube was placed compound 90d (50.0 g, 184 mmol) and NH4OH (150 mL). The resulting mixture was stirred overnight at 100° C. Upon cooling, a solid was collected by filtration and dried in an oven under reduced pressure to obtain the compound 90e as a grey solid (28.0 g, 66% yield), which was used in next step without further purification.

後処理

  1. customInto a 250 mL sealed tube
  2. temperatureUpon cooling
  3. filtrationa solid was collected by filtration
  4. customdried in an oven under reduced pressure

出典と根拠

ORDレコード
ord-d5f3122d6ae94ffd963d262464e523f4
出典データセット
uspto-grants-2016_02
特許番号
US09249163B2

関連ノート

読み込み中…