2-Fluorobenzenesulphonyl chloride → 2-Fluoro-N-(1-methyl-6-oxo-1,6-dihydropyridin-3-yl)benzenesulfonamide
反応式
[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[S:8](Cl)(=[O:10])=[O:9].[NH2:12][C:13]1[CH:14]=[CH:15][C:16](=[O:20])[N:17]([CH3:19])[CH:18]=1>O1CCOCC1.CO>[NH3:12].[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[S:8]([NH:12][C:13]1[CH:14]=[CH:15][C:16](=[O:20])[N:17]([CH3:19])[CH:18]=1)(=[O:10])=[O:9]参加物
6
実験手順
2-Fluorobenzenesulfonyl chloride (0.46 mL, 3.5 mmol) was added to a solution of 5-amino-1-methyl-1,2-dihydropyridin-2-one (478 mg, 3.85 mmol) in 1,4-dioxane (10 mL) and stirred for 28 h at rt. After concentration in vacuo purification by column chromatography eluting with DCM:MeOH:7M NH3 in MeOH (90:5:5) yielded the title compound (448 mg, 1.59 mmol).
後処理
- concentrationAfter concentration
- customin vacuo purification by column chromatography
- washeluting with DCM
出典と根拠
- ORDレコード
- ord-fab72010499b416091a1aafb64c5aa9b
- 出典データセット
- uspto-grants-2016_02
- 特許番号
- US09249160B2
反応ノート
読み込み中…