Boron tribromide → 4-(2-Chloro-6-fluorobenzyl)-2-(4-hydroxy-3,5-di methyl phenyl)-2H-1,2,4-benzothiadiazin-3(4H)-one 1,1-dioxide

HRID 1772956ノート

反応式

HRID 1772956 の反応式
[Cl:1][C:2]1[CH:31]=[CH:30][CH:29]=[C:28]([F:32])[C:3]=1[CH2:4][N:5]1[C:10]2[CH:11]=[CH:12][CH:13]=[CH:14][C:9]=2[S:8](=[O:16])(=[O:15])[N:7]([C:17]2[CH:22]=[C:21]([CH3:23])[C:20]([O:24]C)=[C:19]([CH3:26])[CH:18]=2)[C:6]1=[O:27].B(Br)(Br)Br.OC1C(C)=CC(N2C(=O)N(CC3C(F)=CC(F)=CC=3F)C3C=CC=CC=3S2(=O)=O)=CC=1C>>[Cl:1][C:2]1[CH:31]=[CH:30][CH:29]=[C:28]([F:32])[C:3]=1[CH2:4][N:5]1[C:10]2[CH:11]=[CH:12][CH:13]=[CH:14][C:9]=2[S:8](=[O:15])(=[O:16])[N:7]([C:17]2[CH:18]=[C:19]([CH3:26])[C:20]([OH:24])=[C:21]([CH3:23])[CH:22]=2)[C:6]1=[O:27]

参加物

4

反応物 3

HCID 25134Boron tribromideHCID 727212754-(2-Chloro-6-fluorobenzyl)-2-(4-methoxy-3,5-dimethylphenyl)-2H-1,2,4-benzothiadiazin-3(4H)-one 1,1-dioxideHCID 727218952-(4-Hydroxy-3,5-dimethylphenyl)-4-(2,4,6-trifluorobenzyl)-2H-1,2,4-benzothiadiazin-3(4H)-one 1,1-dioxide

生成物 1

HCID 727219884-(2-Chloro-6-fluorobenzyl)-2-(4-hydroxy-3,5-di methyl phenyl)-2H-1,2,4-benzothiadiazin-3(4H)-one 1,1-dioxide収率 54.2%

実験手順

The title compound (0.12 g, 0.26 mmol) was prepared from (81) (0.23 g, 0.48 mmol) and boron tribromide (1.0M solution in DCM, 0.60 mL, 0.60 mmol) using the methods of (114).

出典と根拠

ORDレコード
ord-dfb982258ce642ada7b089db16857294
出典データセット
uspto-grants-2016_02
特許番号
US09249160B2

反応ノート

読み込み中…