Potassium Carbonate → Acetamide, N-(3-hydroxy-4-nitrophenyl)-
反応式
[C:1]([NH:4][C:5]1[CH:6]=[CH:7][C:8]([N+:15]([O-:17])=[O:16])=[C:9]([O:11]C(=O)C)[CH:10]=1)(=[O:3])[CH3:2].C(=O)([O-])[O-].[K+].[K+]>CO>[OH:11][C:9]1[CH:10]=[C:5]([NH:4][C:1](=[O:3])[CH3:2])[CH:6]=[CH:7][C:8]=1[N+:15]([O-:17])=[O:16]参加物
4
実験手順
A mixture of acetic acid 5-acetylamino-2-nitro-phenyl ester (20.5 g, 85.77 mmol) and potassium carbonate (26 g, 188.4 mmol) in methanol (200 mL) was stirred at room temperature for 3 hours. The reaction mixture was concentrated under reduced pressure, water (250 mL) was added and the resulting mixture was acidified by addition of concentrated hydrochloric acid. The solid which crushed out was triturated, collected by filtration, washed with water and dried under vacuum to afford N-(3-hydroxy-4-nitro-phenyl)-acetamide.
後処理
- concentrationThe reaction mixture was concentrated under reduced pressure, water (250 mL)
- additionwas added
- additionthe resulting mixture was acidified by addition of concentrated hydrochloric acid
- customThe solid which crushed out
- customwas triturated
- filtrationcollected by filtration
- washwashed with water
- customdried under vacuum
出典と根拠
- ORDレコード
- ord-d5291b0c53284b099630f211e21abe93
- 出典データセット
- uspto-grants-2016_02
- 特許番号
- US09255110B2
反応ノート
読み込み中…