Potassium Carbonate → 3-Methoxy-4-nitroaniline
反応式
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([NH:12]C(=O)C)[CH:6]=[CH:7][C:8]=1[N+:9]([O-:11])=[O:10].C(=O)([O-])[O-].[K+].[K+]>Cl>[CH3:1][O:2][C:3]1[CH:4]=[C:5]([NH2:12])[CH:6]=[CH:7][C:8]=1[N+:9]([O-:11])=[O:10]参加物
4
実験手順
A mixture of N-(3-methoxy-4-nitro-phenyl)-acetamide (16.6 g, 78.67 mmol) and an aqueous solution of hydrochloric acid (1.5 M, 200 mL) was refluxed until a clear solution was obtained. The reaction mixture was basified by addition of an aqueous solution of potassium carbonate and then was extracted four times with dichloromethane (200 mL); the combined organic extracts were dried over anhydrous sodium sulfate, filtered and evaporated under reduced pressure to give 13.56 g (quantitative yield) of 3-methoxy-4-nitro-phenylamine as a yellow solid. MS=169 [M+H]+.
後処理
- customwas obtained
- extractionwas extracted four times with dichloromethane (200 mL)
- dry with materialthe combined organic extracts were dried over anhydrous sodium sulfate
- filtrationfiltered
- customevaporated under reduced pressure
出典と根拠
- ORDレコード
- ord-ac32929e6bcd4527ae67a65748c8fc93
- 出典データセット
- uspto-grants-2016_02
- 特許番号
- US09255110B2
反応ノート
読み込み中…