Phosphorus oxychloride → 2-Chloro-7-methoxy-6-nitro-quinoline
反応式
[CH3:1][O:2][C:3]1[CH:12]=[C:11]2[C:6]([CH:7]=[CH:8][C:9](=O)[NH:10]2)=[CH:5][C:4]=1[N+:14]([O-:16])=[O:15].P(Cl)(Cl)([Cl:19])=O>>[Cl:19][C:9]1[CH:8]=[CH:7][C:6]2[C:11](=[CH:12][C:3]([O:2][CH3:1])=[C:4]([N+:14]([O-:16])=[O:15])[CH:5]=2)[N:10]=1参加物
3
反応条件
- 温度
- 110 °C
実験手順
A mixture of 7-methoxy-6-nitro-1H-quinolin-2-one (0.13 g) and phosphorus oxychloride (1 mL) was heated at 110° C. for 2 hours. The resulting mixture was then cooled and poured into ice. The solid which formed was collected by filtration and dried under vacuum to afford 0.119 g of 2-chloro-7-methoxy-6-nitro-quinoline as a brown solid.
後処理
- temperatureThe resulting mixture was then cooled
- additionpoured into ice
- customThe solid which formed
- filtrationwas collected by filtration
- customdried under vacuum
出典と根拠
- ORDレコード
- ord-671a9647a21c45c09945b4809225bf4c
- 出典データセット
- uspto-grants-2016_02
- 特許番号
- US09255110B2
反応ノート
読み込み中…