Water → 6-Bromo-3-iodo-8-(methylthio)imidazo[1,2-b]pyridazine
反応式
[Br:1][C:2]1[CH:3]=[C:4](Br)[C:5]2[N:6]([C:8]([I:11])=[CH:9][N:10]=2)[N:7]=1.[CH3:13][S-:14].[Na+].O>CN1C(=O)CCC1>[Br:1][C:2]1[CH:3]=[C:4]([S:14][CH3:13])[C:5]2[N:6]([C:8]([I:11])=[CH:9][N:10]=2)[N:7]=1参加物
5
実験手順
To a stirred solution of 51.2 g (146.8 mmol) 6,8-dibromo-3-iodoimidazo[1,2-b]pyridazine which was prepared according to intermediate example 96c in NMP (450 mL) are added 12.35 g (176.2 mmol) sodium methanethiolate in one portion at 0° C. After reaction for 15 min, 700 mL water are added and the precipitate is filtered off and dried. Trituration with ether, filtration and drying in vaccuo. yields 44.3 g (65%) of the title compound
後処理
- customAfter reaction for 15 min
- filtrationthe precipitate is filtered off
- customdried
- filtrationTrituration with ether, filtration
- customdrying in vaccuo
出典と根拠
- ORDレコード
- ord-db4f259fceb94086b4aea0c38b4b29b4
- 出典データセット
- uspto-grants-2016_02
- 特許番号
- US09255100B2
反応ノート
読み込み中…