Oxalic Acid → 2-benzylsulfanyl-4-(1-methylpiperidin-4-yloxy)-9,10-dihydro-4H-3,10a-diaza-benzo[f]azulene oxalate

HRID 1773877ノート

反応式

HRID 1773877 の反応式
[CH2:1]([S:8][C:9]1[N:18]=[C:17]2[N:11]([CH2:12][CH2:13][C:14]3[CH:30]=[CH:29][CH:28]=[CH:27][C:15]=3[CH:16]2[O:19][CH:20]2[CH2:25][CH2:24][N:23]([CH3:26])[CH2:22][CH2:21]2)[CH:10]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[C:31]([OH:36])(=[O:35])[C:32]([OH:34])=[O:33]>CC(C)=O>[C:31]([OH:36])(=[O:35])[C:32]([OH:34])=[O:33].[CH2:1]([S:8][C:9]1[N:18]=[C:17]2[N:11]([CH2:12][CH2:13][C:14]3[CH:30]=[CH:29][CH:28]=[CH:27][C:15]=3[CH:16]2[O:19][CH:20]2[CH2:25][CH2:24][N:23]([CH3:26])[CH2:22][CH2:21]2)[CH:10]=1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

参加物

4

反応物 2

HCID 971Oxalic AcidHCID 726947772-benzylsulfanyl-4-(1-methylpiperidin-4-yloxy)-9,10-dihydro-4H-3,10a-diaza-benzo[f]azulene

生成物 1

HCID 867039602-benzylsulfanyl-4-(1-methylpiperidin-4-yloxy)-9,10-dihydro-4H-3,10a-diaza-benzo[f]azulene oxalate

試薬・触媒・溶媒 1

HCID 180Acetone溶媒

実験手順

2-benzylsulfanyl-4-(1-methylpiperidin-4-yloxy)-9,10-dihydro-4H-3,10a-diaza-benzo[f]azulene is dissolved in acetone (0.7 mL) and oxalic acid (1 equivalent) is added. Acetone is removed under reduced pressure to afford the product as an oxalate.

後処理

  1. customAcetone is removed under reduced pressure

出典と根拠

ORDレコード
ord-1796522c75194388a1bf29e91695c0b0
出典データセット
uspto-grants-2016_02
特許番号
US09255101B2

反応ノート

読み込み中…