Potassium Carbonate → 8-(4-tert-Butoxycarbonylmethyl-2-isopropoxy-phenyl)-5-fluoro-3,4-dihydro-1H-isoquinoline-2-carboxylic acid benzyl ester

反応式

[C:1]([O:5][C:6](=[O:19])[CH2:7][C:8]1[CH:13]=[CH:12][C:11](Cl)=[C:10]([O:15][CH:16]([CH3:18])[CH3:17])[CH:9]=1)([CH3:4])([CH3:3])[CH3:2].[CH2:20]([O:27][C:28]([N:30]1[CH2:39][CH2:38][C:37]2[C:32](=[C:33](B3OC(C)(C)C(C)(C)O3)[CH:34]=[CH:35][C:36]=2[F:40])[CH2:31]1)=[O:29])[C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1.C(=O)([O-])[O-].[K+].[K+]>C1(C)C=CC=CC=1.O.CC(P(C(C)(C)C)C1C=CC(N(C)C)=CC=1)(C)C.CC(P(C(C)(C)C)C1C=CC(N(C)C)=CC=1)(C)C.Cl[Pd]Cl>[CH2:20]([O:27][C:28]([N:30]1[CH2:39][CH2:38][C:37]2[C:32](=[C:33]([C:11]3[CH:12]=[CH:13][C:8]([CH2:7][C:6]([O:5][C:1]([CH3:4])([CH3:3])[CH3:2])=[O:19])=[CH:9][C:10]=3[O:15][CH:16]([CH3:18])[CH3:17])[CH:34]=[CH:35][C:36]=2[F:40])[CH2:31]1)=[O:29])[C:21]1[CH:22]=[CH:23][CH:24]=[CH:25][CH:26]=1