化工社化工社 化学情報印刷レポート · 研究参考用
Methanol → 6-Nitrohexanoic acid methyl ester
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Methanol | HCID 887 | — |
| 反応物 | 2-Nitrocyclohexanone | HCID 521241 | — |
| 生成物 | 6-Nitrohexanoic acid methyl ester | HCID 11084387 | — |
反応手順
Commercially available 2-nitrocyclohexanone was refluxed in MeOH in presence of Amberlyst A21 to give 6-nitrohexanoic acid methyl ester 1. Reaction of 1 with N,N′-dibenzylethylenediamine diacetate and paraformaldehyde gave diazepine 2 which was firstly hydrogenated to 3 and then alkylated with t-butyl bromoacetate to give pentaester 4. Selective hydrolysis of 4 by means of LiOH in THF/H2O gave 5. Overall yield 13%.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US09259491B2 |
| 出典データセット | uspto-grants-2016_02 |
| ORD ID | ord-72a2b74f5be64729a476e46c8cebb6e6 |
| 出典メモ | uspto-grants-2016_02 |