Dibenzofuran → Dibenzofuran-2-ylethan-2-one

HRID 17746

反応式

HRID 17746 の反応式
[CH:1]1[C:9]2[C:8]3[CH:10]=[CH:11][CH:12]=[CH:13][C:7]=3[O:6][C:5]=2[CH:4]=[CH:3][CH:2]=1.[Al+3].[Cl-].[Cl-].[Cl-].[C:18](Cl)(=[O:20])[CH3:19]>C(Cl)Cl>[CH:1]1[C:9]2[C:8]3[CH:10]=[CH:11][CH:12]=[CH:13][C:7]=3[O:6][C:5]=2[CH:4]=[CH:3][C:2]=1[CH2:19][CH:18]=[O:20]

参加物

5

反応物 3

HCID 568DibenzofuranHCID 6367Acetyl chlorideHCID 6451240Aluminum(III) Chloride

生成物 1

HCID 13477039Dibenzofuran-2-ylethan-2-one

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

反応条件

温度
0 °C

実験手順

A solution of dibenzofuran (0.5 mmol) in anhydrous DCM was cooled to 0° C. AlCl3 (1.5 eq., 0.75 mmol) was added followed by a slow addition of acetyl chloride (1.5 eq., 0.75 mmol). The reaction mixture was stirred at 0° C. for 2-3 h or until the completion of reaction. The product was extracted with DCM and washed with saturated sodium bicarbonate solution. The organic layer was dried over anhydrous sodium sulfate and concenterated in vacuo to give dibenzofuran-2-ylethan-2-one.

後処理

  1. extractionThe product was extracted with DCM
  2. washwashed with saturated sodium bicarbonate solution
  3. dry with materialThe organic layer was dried over anhydrous sodium sulfate

出典と根拠

ORDレコード
ord-dde33f8697034d5b92476b07d2715063
出典データセット
uspto-grants-2010_06
特許番号
US07737285B2

関連ノート

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