Iodine → HCID 178506572、化合物

HRID 1774952ノート

反応式

HRID 1774952 の反応式
[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([C:7]2[CH:8]=[C:9]3[CH:15]=[N:14][NH:13][C:10]3=[CH:11][N:12]=2)[CH:2]=1.[OH-].[K+].[I:18]I>CN(C=O)C>[I:18][C:15]1[C:9]2[C:10](=[CH:11][N:12]=[C:7]([C:3]3[CH:2]=[N:1][CH:6]=[CH:5][CH:4]=3)[CH:8]=2)[NH:13][N:14]=1

参加物

5

反応物 3

HCID 807IodineHCID 14797Potassium HydroxideHCID 866766805-(pyridin-3-yl)-1H-pyrazolo[3,4-c]pyridine

生成物 1

HCID 178506572HCID 178506572、化合物収率 90%

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

5-(Pyridin-3-yl)-1H-pyrazolo[3,4-c]pyridine (196 g, 1 mol) was dissolved in 1000 mL DMF. KOH (112 g, 2 mol) was added. After stirring for 30 min, I2 (303 g, 1.2 mol) was added. The mixture was stirred for 1 h at room temperature. After reaction, the reaction was quenched with saturated aq. Na2S2O5 solution followed by the addition water (5 L). The solid was filtered and washed with water to give 3-iodo-5-(pyridin-3-yl)-1H-pyrazolo[3,4-c]pyridine as a yellow solid (290 g, 90%)

後処理

  1. stirringThe mixture was stirred for 1 h at room temperature
  2. customAfter reaction
  3. customthe reaction was quenched with saturated aq. Na2S2O5 solution
  4. additionfollowed by the addition water (5 L)
  5. filtrationThe solid was filtered
  6. washwashed with water

出典と根拠

ORDレコード
ord-823187ec546d44e9b922ffba1fd7348d
出典データセット
uspto-grants-2016_02
特許番号
US09260425B2

反応ノート

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