Pivaloyl chloride → HCID 136242920、化合物
反応式
[F:1][C:2]1[CH:3]=[C:4]([C:16]([O:18]C)=O)[C:5]2[C:6]3[C:14](=O)[CH2:13][NH:12][CH2:11][C:7]=3[NH:8][C:9]=2[CH:10]=1.[C:20](Cl)(=[O:25])[C:21]([CH3:24])([CH3:23])[CH3:22].C1(C(N2CC3NC4C=CC=C5C(=O)[NH:46][N:47]=C(C=3C=45)C2)=O)CC1>>[F:1][C:2]1[CH:3]=[C:4]2[C:16](=[O:18])[NH:46][N:47]=[C:14]3[C:6]4[C:5]2=[C:9]([NH:8][C:7]=4[CH2:11][N:12]([C:20](=[O:25])[C:21]([CH3:24])([CH3:23])[CH3:22])[CH2:13]3)[CH:10]=1参加物
4
実験手順
Compound 52 was prepared from methyl 7-fluoro-4-oxo-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-5-carboxylate and pivaloyl chloride according to the procedures similar to those for Compound 47. 1H NMR (DMSO-d6) δ 11.9 (s, 1H), 10.2 (s, 1H), 7.45 (dd, 1H, J=2.4, 9.6 Hz), 7.22 (dd, 1H, J=2.4, 10.2 Hz), 4.92 (s, 2H), 4.42 (s, 2H), and 1.24 (s, 9H). MS (ESI) m/e [M+1]+ 329.
出典と根拠
- ORDレコード
- ord-adf530b9204747cbbbf4008024ed71ce
- 出典データセット
- uspto-grants-2016_02