Hydrochloric Acid → 1-(5-Methyl-1,2,4-oxadiazol-3-yl)piperazine hydrochloride

HRID 1775321ノート

反応式

HRID 1775321 の反応式
[CH3:1][C:2]1[O:6][N:5]=[C:4]([N:7]2[CH2:12][CH2:11][N:10](C(OC(C)(C)C)=O)[CH2:9][CH2:8]2)[N:3]=1.[ClH:20].O1CCOCC1>C(OCC)C>[ClH:20].[CH3:1][C:2]1[O:6][N:5]=[C:4]([N:7]2[CH2:12][CH2:11][NH:10][CH2:9][CH2:8]2)[N:3]=1

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 312751,4-DioxaneHCID 86686046tert-Butyl 4-(5-methyl-1,2,4-oxadiazol-3-yl)piperazine-1-carboxylate

生成物 1

HCID 866860471-(5-Methyl-1,2,4-oxadiazol-3-yl)piperazine hydrochloride

試薬・触媒・溶媒 1

HCID 3283Diethyl Ether溶媒

実験手順

To a solution of tert-butyl 4-(5-methyl-1,2,4-oxadiazol-3-yl)piperazine-1-carboxylate (507 mg, 1.890 mmol) in diethyl ether (12 mL) was added HCl, 4N in dioxane (7 mL, 28.0 mmol) and the reaction was stirred at room temperature over the weekend. The precipitate was isolated by filtration, washed with diethylether and dried under reduced pressure after which 330 mg of a white solid were obtained (1.612 mmol, 85%). MS (ESI) m/z=169.2 [M+1]+.

後処理

  1. customThe precipitate was isolated by filtration
  2. washwashed with diethylether
  3. dry with materialdried under reduced pressure after which 330 mg of a white solid
  4. customwere obtained (1.612 mmol, 85%)

出典と根拠

ORDレコード
ord-d9037ac3eb424c3290e27dfc9adeecb1
出典データセット
uspto-grants-2016_02
特許番号
US09260441B2

反応ノート

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