Hydrochloric Acid → 1-(4-Methylpyridin-2-YL)-1,4-diazepane dihydrochloride
反応式
[CH3:1][C:2]1[CH:7]=[CH:6][N:5]=[C:4]([N:8]2[CH2:14][CH2:13][CH2:12][N:11](C(OC(C)(C)C)=O)[CH2:10][CH2:9]2)[CH:3]=1.[ClH:22]>C(Cl)Cl>[ClH:22].[ClH:22].[CH3:1][C:2]1[CH:7]=[CH:6][N:5]=[C:4]([N:8]2[CH2:14][CH2:13][CH2:12][NH:11][CH2:10][CH2:9]2)[CH:3]=1参加物
4
実験手順
tert-Butyl 4-(4-methyl-2-pyridyl)-1,4-diazepane-1-carboxylate (91 mg, 0.312 mmol) was dissolved in DCM under nitrogen. Hydrochloric acid (4N in dioxane, 1.56 ml, 6.25 mmol) was added and the mixture was stirred at room temperature overnight. The mixture was evaporated under reduced pressure to give 84 mg of a solid (quantitative). MS (ESI) m/z=192.2 [M+1]+.
後処理
- customThe mixture was evaporated under reduced pressure
出典と根拠
- ORDレコード
- ord-a280c5f7ab0341599c4603ad1af6eb67
- 出典データセット
- uspto-grants-2016_02
- 特許番号
- US09260441B2
反応ノート
読み込み中…