Hydrochloric Acid → 2-Methyl-3-(piperidin-4-yl)pyridine hydrochloride
反応式
[CH3:1][C:2]1[C:7]([CH:8]2[CH2:13][CH2:12][N:11](C(OC(C)(C)C)=O)[CH2:10][CH2:9]2)=[CH:6][CH:5]=[CH:4][N:3]=1.[ClH:21]>CO>[ClH:21].[CH3:1][C:2]1[C:7]([CH:8]2[CH2:13][CH2:12][NH:11][CH2:10][CH2:9]2)=[CH:6][CH:5]=[CH:4][N:3]=1参加物
4
実験手順
tert-Butyl 4-(2-methyl-3-pyridyl)piperidine-1-carboxylate (100 mg, 0.36 mmol) was dissolved in methanol (4 ml) and combined with hydrochloric acid (4N in dioxane, 10 ml) and the mixture was stirred at room temperature for two hours. The volatiles were removed under reduced pressure to yield 54 mg of a beige solid (0.25 mmol, 69%) MS (ESI) m/z=177.1 [M+1]+.
後処理
- customThe volatiles were removed under reduced pressure
出典と根拠
- ORDレコード
- ord-ac158981a4d1402f8019e38bc8b14812
- 出典データセット
- uspto-grants-2016_02
- 特許番号
- US09260441B2
反応ノート
読み込み中…