Hydrochloric Acid → Ethyl 5-(methylamino)-2-(piperazin-1-yl)thiazole-4-carboxylate hydrochloride

HRID 1775355ノート

反応式

HRID 1775355 の反応式
C(OC([N:8]1[CH2:13][CH2:12][N:11]([C:14]2[S:15][C:16]([NH:24][CH3:25])=[C:17]([C:19]([O:21][CH2:22][CH3:23])=[O:20])[N:18]=2)[CH2:10][CH2:9]1)=O)(C)(C)C.[ClH:26]>C(OCC)C.C(O)C>[ClH:26].[CH3:25][NH:24][C:16]1[S:15][C:14]([N:11]2[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]2)=[N:18][C:17]=1[C:19]([O:21][CH2:22][CH3:23])=[O:20]

参加物

5

反応物 2

HCID 313Hydrochloric AcidHCID 89825828Ethyl 2-(4-tert-butoxycarbonylpiperazin-1-yl)-5-methylamino-thiazole-4-carboxylate

生成物 1

HCID 89826078Ethyl 5-(methylamino)-2-(piperazin-1-yl)thiazole-4-carboxylate hydrochloride

試薬・触媒・溶媒 2

HCID 702Ethanol溶媒HCID 3283Diethyl Ether溶媒

実験手順

Ethyl 2-(4-tert-butoxycarbonylpiperazin-1-yl)-5-methylamino-thiazole-4-carboxylate (196 mg, 0.529 mmol) was dissolved in a mixture of diethylether (10 ml) and ethanol (absolute, 15 ml), hydrochloric acid (4N in dioxane, 5 ml) was added and the mixture was stirred at room temperature for two days. The resulting precipitate was collected by filtration, washed with diethylether and dried under reduced pressure to give 130 mg of a white solid (0.424 mmol, yield 80) MS (multi-mode) m/z=271.1 [M+1]+.

後処理

  1. additionwas added
  2. filtrationThe resulting precipitate was collected by filtration
  3. washwashed with diethylether
  4. customdried under reduced pressure

出典と根拠

ORDレコード
ord-2713baebf79c484eb0207233db39d5c9
出典データセット
uspto-grants-2016_02
特許番号
US09260441B2

反応ノート

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