Sodium ethoxide → HCID 89826007、化合物
反応式
[Br:1][C:2]1[CH:7]=[C:6]([N+]([O-])=O)[CH:5]=[C:4]([CH3:11])[N+:3]=1[O-:12].[O-:13][CH2:14][CH3:15].[Na+]>C(O)C>[Br:1][C:2]1[CH:7]=[C:6]([O:13][CH2:14][CH3:15])[CH:5]=[C:4]([CH3:11])[N+:3]=1[O-:12]参加物
4
実験手順
2-Bromo-6-methyl-4-nitro-pyridine 1-oxide (1 g, 4.3 mmol) was dissolved in ethanol (anhydrous, 50 ml), and sodium ethoxide (21% in ethanol, 1.4 ml, 4.3 mmol) was added dropwise with stirring. The mixture was stirred at room temperature overnight, concentrated under reduced pressure, the residue was taken up in DCM (50 ml), the mixture was washed with water (50 ml), dried (sodium sulfate) and concentrated under reduced pressure to yield 0.84 g of brown yellow crystals (3.6 mmol, 84%).
後処理
- stirringThe mixture was stirred at room temperature overnight
- concentrationconcentrated under reduced pressure
- washthe mixture was washed with water (50 ml)
- dry with materialdried (sodium sulfate)
- concentrationconcentrated under reduced pressure
出典と根拠
- ORDレコード
- ord-e5ae67b001544e7cbbf79b18a5c49923
- 出典データセット
- uspto-grants-2016_02
- 特許番号
- US09260441B2
反応ノート
読み込み中…