Ethanol → 3-(2-Aminoethyl)-6-fluoro-5-methoxy-1H-indole-2-carboxylic acid

HRID 1775434ノート

反応式

HRID 1775434 の反応式
[F:1][C:2]1[CH:10]=[C:9]2[C:5]([C:6]3[CH2:14][CH2:13][NH:12][C:11](=[O:15])[C:7]=3[NH:8]2)=[CH:4][C:3]=1[O:16][CH3:17].C([OH:20])C.[OH-].[K+]>O>[NH2:12][CH2:13][CH2:14][C:6]1[C:5]2[C:9](=[CH:10][C:2]([F:1])=[C:3]([O:16][CH3:17])[CH:4]=2)[NH:8][C:7]=1[C:11]([OH:20])=[O:15]

参加物

5

反応物 3

HCID 702EthanolHCID 14797Potassium Hydroxide2 回HCID 616433HCID 616433、化合物

生成物 1

HCID 6164323-(2-Aminoethyl)-6-fluoro-5-methoxy-1H-indole-2-carboxylic acid

試薬・触媒・溶媒 1

HCID 962Water溶媒

反応条件

温度
80 °C

実験手順

To a mixture of 7-fluoro-6-methoxy-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-one (780 mg), ethanol (5.00 mL), and water (5.00 mL) was added potassium hydroxide (1.58 g), followed by stirring at 80° C. overnight. Potassium hydroxide (1.58 g) was added to the reaction mixture, followed by stirring at 100° C. for 6 hours. After cooling to room temperature, the solvent was evaporated under reduced pressure. The obtained residue was dissolved in water (10.0 mL), to the mixture was added acetic acid (3.00 mL), and the precipitated solid was collected by filtration and dried under reduced pressure to obtain 3-(2-aminoethyl)-6-fluoro-5-methoxy-1H-indole-2-carboxylic acid (607 mg) as a reddish brown solid.

後処理

  1. stirringby stirring at 100° C. for 6 hours
  2. temperatureAfter cooling to room temperature
  3. customthe solvent was evaporated under reduced pressure
  4. dissolutionThe obtained residue was dissolved in water (10.0 mL), to the mixture
  5. additionwas added acetic acid (3.00 mL)
  6. filtrationthe precipitated solid was collected by filtration
  7. customdried under reduced pressure

出典と根拠

ORDレコード
ord-009a54eb703a47618c578a868e0d79cc
出典データセット
uspto-grants-2016_02
特許番号
US09260445B2

反応ノート

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