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4-Chloroaniline → 3-(4-Chlorophenyl)-7-phenylthieno[3,2-d]pyrimidin-4(3H)-one
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 4-Chloroaniline | HCID 7812 | — |
| 反応物 | Ethyl orthoformate | HCID 31214 | — |
| 反応物 | Methyl 3-amino-4-phenylthiophene-2-carboxylate | HCID 2759782 | — |
| 反応物 | 3,7-Diphenylthieno[3,2-d]pyrimidin-4(3H)-one | HCID 78324865 | — |
| 溶媒 | Acetic Acid | HCID 176 | — |
| 生成物 | 3-(4-Chlorophenyl)-7-phenylthieno[3,2-d]pyrimidin-4(3H)-one | HCID 78324871 | 36% |
反応手順
In the same manner as the synthesis of Compound 1, methyl 3-amino-4-phenylthiophene-2-carboxylate (60 mg, 0.26 mmol), triethyl orthoformate (0.5 ml), 4-chloroaniline (61 mg, 0.48 mmol), and acetic acid (0.06 ml) were used to give 31.6 mg (0.093 mmol, 36% yield) of the title compound.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US09260448B2 |
| 出典データセット | uspto-grants-2016_02 |
| ORD ID | ord-5a958cc719064c4fa99885c901bb0df5 |
| 出典メモ | uspto-grants-2016_02 |