4-Chloroaniline → 3-(4-Chlorophenyl)-7-phenylthieno[3,2-d]pyrimidin-4(3H)-one

HRID 1775608

反応式

HRID 1775608 の反応式
[C:1]1([N:7]2[C:12](=[O:13])[C:11]3[S:14][CH:15]=[C:16]([C:17]4[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=4)[C:10]=3[N:9]=[CH:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.NC1C(C2C=CC=CC=2)=CSC=1C(OC)=O.C(OCC)(OCC)OCC.[Cl:49]C1C=CC(N)=CC=1>C(O)(=O)C>[Cl:49][C:4]1[CH:5]=[CH:6][C:1]([N:7]2[C:12](=[O:13])[C:11]3[S:14][CH:15]=[C:16]([C:17]4[CH:18]=[CH:19][CH:20]=[CH:21][CH:22]=4)[C:10]=3[N:9]=[CH:8]2)=[CH:2][CH:3]=1

参加物

6

反応物 4

HCID 78124-ChloroanilineHCID 31214Ethyl orthoformateHCID 2759782Methyl 3-amino-4-phenylthiophene-2-carboxylateHCID 783248653,7-Diphenylthieno[3,2-d]pyrimidin-4(3H)-one

生成物 1

HCID 783248713-(4-Chlorophenyl)-7-phenylthieno[3,2-d]pyrimidin-4(3H)-one収率 36%

試薬・触媒・溶媒 1

HCID 176Acetic Acid溶媒

実験手順

In the same manner as the synthesis of Compound 1, methyl 3-amino-4-phenylthiophene-2-carboxylate (60 mg, 0.26 mmol), triethyl orthoformate (0.5 ml), 4-chloroaniline (61 mg, 0.48 mmol), and acetic acid (0.06 ml) were used to give 31.6 mg (0.093 mmol, 36% yield) of the title compound.

出典と根拠

ORDレコード
ord-5a958cc719064c4fa99885c901bb0df5
出典データセット
uspto-grants-2016_02
特許番号
US09260448B2

関連ノート

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