3-Bromoaniline → 3-(3-Bromophenyl)-7-phenylthieno[3,2-d]pyrimidin-4(3H)-one

HRID 1775609

反応式

HRID 1775609 の反応式
[C:1]1([N:7]2[C:12](=[O:13])[C:11]3[S:14][CH:15]=[C:16]([C:17]4[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=4)[C:10]=3[N:9]=[CH:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.NC1C(C2C=CC=CC=2)=CSC=1C(OC)=O.C(OCC)(OCC)OCC.[Br:49]C1C=C(C=CC=1)N>C(O)(=O)C>[Br:49][C:3]1[CH:2]=[C:1]([N:7]2[C:12](=[O:13])[C:11]3[S:14][CH:15]=[C:16]([C:17]4[CH:18]=[CH:19][CH:20]=[CH:21][CH:22]=4)[C:10]=3[N:9]=[CH:8]2)[CH:6]=[CH:5][CH:4]=1

参加物

6

反応物 4

HCID 115623-BromoanilineHCID 31214Ethyl orthoformateHCID 2759782Methyl 3-amino-4-phenylthiophene-2-carboxylateHCID 783248653,7-Diphenylthieno[3,2-d]pyrimidin-4(3H)-one

生成物 1

HCID 783248723-(3-Bromophenyl)-7-phenylthieno[3,2-d]pyrimidin-4(3H)-one収率 12%

試薬・触媒・溶媒 1

HCID 176Acetic Acid溶媒

実験手順

In the same manner as the synthesis of Compound 1, methyl 3-amino-4-phenylthiophene-2-carboxylate (200 mg, 0.86 mmol), triethyl orthoformate (2 ml), 3-bromoaniline (280 mg, 1.63 mmol), and acetic acid (0.2 ml) were used to give 40 mg (0.10 mmol, 12% yield) of the title compound.

出典と根拠

ORDレコード
ord-264be8b8c0e44d28a65ebf3d2377c035
出典データセット
uspto-grants-2016_02
特許番号
US09260448B2

関連ノート

読み込み中…