Acetic Acid → 3-(4-Methoxyphenyl)-2-methyl-7-phenylthieno[3,2-d]pyrimidin-4(3H)-one

HRID 1775668ノート

反応式

HRID 1775668 の反応式
[NH2:1][C:2]1[C:6]([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=2)=[CH:5][S:4][C:3]=1[C:13]([NH:15][C:16]1[CH:21]=[CH:20][C:19]([O:22][CH3:23])=[CH:18][CH:17]=1)=[O:14].[C:24](OCC)(OCC)(OCC)[CH3:25].C(O)(=O)C.C(OCC)C>CCOC(C)=O>[CH3:23][O:22][C:19]1[CH:18]=[CH:17][C:16]([N:15]2[C:13](=[O:14])[C:3]3[S:4][CH:5]=[C:6]([C:7]4[CH:8]=[CH:9][CH:10]=[CH:11][CH:12]=4)[C:2]=3[N:1]=[C:24]2[CH3:25])=[CH:21][CH:20]=1

参加物

6

反応物 4

HCID 176Acetic AcidHCID 3283Diethyl EtherHCID 66221Triethyl orthoacetateHCID 867298003-Amino-N-(4-methoxyphenyl)-4-phenylthiophene-2-carboxamide

生成物 1

HCID 783226943-(4-Methoxyphenyl)-2-methyl-7-phenylthieno[3,2-d]pyrimidin-4(3H)-one収率 21%

試薬・触媒・溶媒 1

HCID 8857Ethyl Acetate溶媒

実験手順

3-Amino-N-(4-methoxyphenyl)-4-phenylthiophene-2-carboxamide (57 mg, 0.18 mmol), triethyl orthoacetate (1 ml), and acetic acid (0.1 ml) were placed in a pressure bottle. The mixture was heated with stiffing at 160° C. for 18 hr. After the completion of the reaction was confirmed by TLC, the reaction mixture was cooled to room temperature and solidified with diethyl ether and EtOAc to give 13 mg (0.037 mmol, 21% yield) of the title compound.

後処理

  1. temperatureThe mixture was heated

出典と根拠

ORDレコード
ord-ce52aa5e3eab4902988d9082d362f262
出典データセット
uspto-grants-2016_02
特許番号
US09260448B2

反応ノート

読み込み中…