Ethanol → 5-(4-Methoxyphenyl)-2,2-dimethylfuran-3(2H)-one

HRID 1776283ノート

反応式

HRID 1776283 の反応式
O[C:2]([CH3:16])([CH3:15])[C:3]#[C:4][C:5]([C:7]1[CH:12]=[CH:11][C:10]([O:13][CH3:14])=[CH:9][CH:8]=1)=[O:6].CC[OH:19]>>[CH3:14][O:13][C:10]1[CH:11]=[CH:12][C:7]([C:5]2[O:6][C:2]([CH3:16])([CH3:15])[C:3](=[O:19])[CH:4]=2)=[CH:8][CH:9]=1

参加物

3

反応物 2

HCID 702Ethanol2 回HCID 127225774-Hydroxy-1-(4-methoxyphenyl)-4-methylpent-2-yn-1-one

生成物 1

HCID 145333195-(4-Methoxyphenyl)-2,2-dimethylfuran-3(2H)-one収率 92%

実験手順

To a stirred solution of 4-hydroxy-1-(4-methoxyphenyl)-4-methylpent-2-yn-1-one (6 g, 0.027 mol) in ethanol (100 mL) diethyl amine (2.86 g, 0.027 mol) in EtOH (15 mL) was added dropwise at RT and the reaction mixture was stirred for additional 4 h. The EtOH was then removed and the mixture diluted with EtOAc (100 mL). The combined organic layers were washed with water (50 mL) and brine (20 mL), dried over Na2SO4, filtered and concentrated in vacuo to afford 5-(4-methoxyphenyl)-2,2-dimethylfuran-3(2H)-one (5.5 g, 92%).

後処理

  1. customThe EtOH was then removed
  2. additionthe mixture diluted with EtOAc (100 mL)
  3. washThe combined organic layers were washed with water (50 mL) and brine (20 mL)
  4. dry with materialdried over Na2SO4
  5. filtrationfiltered
  6. concentrationconcentrated in vacuo

出典と根拠

ORDレコード
ord-ef46b98217d54fecbbb9280dac1836a5
出典データセット
uspto-grants-2016_02
特許番号
US09265767B2

反応ノート

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