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4-Nitrobenzylamine hydrochloride → (S)-3,5-dichloro-4-(2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)-2-(4-nitrobenzylcarbamoyloxy)ethyl)pyridine 1-oxide

HRID 1776462
ノート
印刷プレビュー

反応式

HRID 1776462 の反応式
[Cl:1][C:2]1[CH:3]=[N+:4]([O-:39])[CH:5]=[C:6]([Cl:38])[C:7]=1[CH2:8][C@@H:9]([C:23]1[CH:28]=[CH:27][C:26]([O:29][CH:30]([F:32])[F:31])=[C:25]([O:33][CH2:34][CH:35]2[CH2:37][CH2:36]2)[CH:24]=1)[O:10][C:11](OC1C=CC([N+]([O-])=O)=CC=1)=[O:12].Cl.[N+:41]([C:44]1[CH:49]=[CH:48][C:47]([CH2:50][NH2:51])=[CH:46][CH:45]=1)([O-:43])=[O:42]>C(Cl)Cl.CN(C1C=CN=CC=1)C>[Cl:38][C:6]1[CH:5]=[N+:4]([O-:39])[CH:3]=[C:2]([Cl:1])[C:7]=1[CH2:8][C@@H:9]([C:23]1[CH:28]=[CH:27][C:26]([O:29][CH:30]([F:31])[F:32])=[C:25]([O:33][CH2:34][CH:35]2[CH2:37][CH2:36]2)[CH:24]=1)[O:10][C:11](=[O:12])[NH:51][CH2:50][C:47]1[CH:46]=[CH:45][C:44]([N+:41]([O-:43])=[O:42])=[CH:49][CH:48]=1
参加物実験手順後処理出典と根拠反応ノート

参加物

5

反応物 2

HCID 112524674-Nitrobenzylamine hydrochlorideHCID 86679418(S)-3,5-dichloro-4-(2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)-2-((4-nitrophenoxy)-carbonyloxy)ethyl)pyridine 1-oxide

生成物 1

HCID 86679419(S)-3,5-dichloro-4-(2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)-2-(4-nitrobenzylcarbamoyloxy)ethyl)pyridine 1-oxide収率 86.1%

試薬・触媒・溶媒 2

HCID 14284
4-(Dimethylamino)pyridine
触媒
HCID 6344Dichloromethane溶媒2 回

実験手順

To a stirred solution of compound (S)-3,5-dichloro-4-(2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)-2-((4-nitrophenoxy)-carbonyloxy)ethyl)pyridine 1-oxide, (227 mg, 0.388 mmol) in DCM (10 ml), (4-nitrophenyl)methanamine hydrochloride (88 mg, 0.465 mmol), and DMAP (56.9 mg, 0.465 mmol) were added. The reaction mixture was stirred at RT overnight. After 20 hours, the mixture was diluted with DCM and washed with a solution of K2CO3. he organic layer was dried over Na2SO4, evaporated and the resulting crude was purified by flash chromatography on silica gel (DCM:MeOH 10:0.3) affording the desired product (200 mg, 0.334 mmol, 86% yield, MS/ESI+ 598.3 [MH]+).

後処理

  1. waitAfter 20 hours
  2. washwashed with a solution of K2CO3
  3. dry with materialhe organic layer was dried over Na2SO4
  4. customevaporated
  5. customthe resulting crude was purified by flash chromatography on silica gel (DCM:MeOH 10:0.3)

出典と根拠

ORDレコード
ord-c53770f542cc4830a83d9b53dd8c0f96
出典データセット
uspto-grants-2016_02
DOI
10.6084/m9.figshare.5104873.v1
特許番号
US09265768B2

反応ノート

読み込み中…

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