1,2-Dichloroethane → 2-(Benzyloxy)-2-oxoethyl 4-(methylsulfonamido-methyl)benzoate

HRID 1776559ノート

反応式

HRID 1776559 の反応式
[CH3:1][S:2]([NH:5][CH2:6][C:7]1[CH:15]=[CH:14][C:10]([C:11]([OH:13])=[O:12])=[CH:9][CH:8]=1)(=[O:4])=[O:3].O[CH2:17][C:18]([O:20][CH2:21][C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1)=[O:19].C(Cl)CCl>C(Cl)Cl.C(Cl)Cl.CO.CN(C1C=CN=CC=1)C>[CH3:1][S:2]([NH:5][CH2:6][C:7]1[CH:15]=[CH:14][C:10]([C:11]([O:13][CH2:17][C:18]([O:20][CH2:21][C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=2)=[O:19])=[O:12])=[CH:9][CH:8]=1)(=[O:4])=[O:3]

参加物

7

反応物 3

HCID 111,2-DichloroethaneHCID 561337Benzyl 2-hydroxyacetateHCID 15066094-{[(Methylsulfonyl)amino]methyl}benzoic acid

生成物 1

HCID 866795152-(Benzyloxy)-2-oxoethyl 4-(methylsulfonamido-methyl)benzoate収率 60.7%

試薬・触媒・溶媒 3

HCID 142844-(Dimethylamino)pyridine触媒HCID 6344Dichloromethane溶媒HCID 21226129Dichloromethane methanol溶媒

実験手順

To a solution of 4-(methylsulfonamidomethyl)benzoic acid (0.4 g, 1.745 mmol) and benzyl 2-hydroxyacetate (0.290 g, 1.745 mmol) in a mixture of DCM and THF 1/1 (50 ml), EDC (0.334 g, 1.745 mmol) and DMAP (0.256 g, 2.094 mmol) were added in one portion. The reaction was stirred at RT for 3 hours. The solvent was removed under vacuum and the resulting crude was portioned between EtOAc and HCl 2N. The organic phase was separated, washed with brine and dried over Na2SO4. The solvent was removed under vacuum affording 2-(benzyloxy)-2-oxoethyl 4-(methylsulfonamido-methyl)benzoate (0.4 g, 1.060 mmol, 60.7% yield, MS/ESI+ 377.9 [MH]+). This product was employed in the following step without any further purification.

後処理

  1. additionwere added in one portion
  2. customThe solvent was removed under vacuum
  3. customThe organic phase was separated
  4. washwashed with brine
  5. dry with materialdried over Na2SO4
  6. customThe solvent was removed under vacuum

出典と根拠

ORDレコード
ord-ac348c8047d345f4a89be2d61033404a
出典データセット
uspto-grants-2016_02
特許番号
US09265768B2

反応ノート

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