Phosphorus oxychloride → 8-(Benzyloxy)-2-chloroquinoline

HRID 1777172ノート

反応式

HRID 1777172 の反応式
[CH2:1]([O:8][C:9]1[CH:10]=[CH:11][CH:12]=[C:13]2[C:18]=1[N:17]=[C:16](O)[CH:15]=[CH:14]2)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.O=P(Cl)(Cl)[Cl:22]>>[CH2:1]([O:8][C:9]1[CH:10]=[CH:11][CH:12]=[C:13]2[C:18]=1[N:17]=[C:16]([Cl:22])[CH:15]=[CH:14]2)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

参加物

3

反応物 2

HCID 24813Phosphorus oxychlorideHCID 178515619HCID 178515619、化合物

生成物 1

HCID 220422348-(Benzyloxy)-2-chloroquinoline収率 85%

反応条件

温度
90 °C

実験手順

8-(benzyloxy)quinolin-2-ol (6.6 g, 26.3 mmol) was dissolved in POCl3 (50 mL). The mixture was stirred at 90° C. for 16 h. The POCl3 was evaporated and to the residue was added EtOAc (100 mL) and the solution was washed with a.q. NaHCO3 (80 mL) and H2O (80 mL). The EtOAc was removed under vacuum to give the desired compound (6.0 g, yield 85%). LCMS (m/z): 270.1 [M+H]+

後処理

  1. customThe POCl3 was evaporated and to the residue
  2. additionwas added EtOAc (100 mL)
  3. washthe solution was washed with a.q
  4. customThe EtOAc was removed under vacuum

出典と根拠

ORDレコード
ord-fb616de908884d78bb8380893a5ff4d4
出典データセット
uspto-grants-2016_02
特許番号
US09266836B2

反応ノート

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