Hydrochloric Acid → HCID 58970539、化合物
反応式
Cl.C(OC([N:9]1[CH2:14][CH2:13][C:12]([CH2:18][CH:19]([CH3:21])[CH3:20])([C:15]([OH:17])=[O:16])[CH2:11][CH2:10]1)=O)(C)(C)C>O1CCOCC1>[CH2:18]([C:12]1([C:15]([OH:17])=[O:16])[CH2:11][CH2:10][NH:9][CH2:14][CH2:13]1)[CH:19]([CH3:21])[CH3:20]参加物
4
実験手順
A solution of hydrochloric acid (12N, 1.2 mL) in 1,4-dioxane (2.4 mL) is added to 4-isobutylpiperidine-1,4-dicarboxylic acid monotertbutyl ester (0.7 g, 0.0025 mol) and stirred at room temperature for 1 hr. The reaction mixture is concentrated under reduced pressure and the residue is treated with saturated solution of sodium bicarbonate (0.5 mL) to adjust the pH to ˜7. It is again concentrate under reduced pressure to get crude 4-isobutylpiperidine-4-carboxylic acid.
後処理
- concentrationThe reaction mixture is concentrated under reduced pressure
- additionthe residue is treated with saturated solution of sodium bicarbonate (0.5 mL)
- concentrationIt is again concentrate under reduced pressure
出典と根拠
- ORDレコード
- ord-f1695c4a314746b992d4439a3af5c3e0
- 出典データセット
- uspto-grants-2016_02
- 特許番号
- US09266867B2
反応ノート
読み込み中…