{4-[5-(2-Chlorobiphenyl-4-yl)-[1,2,4]-oxadiazol-3-yl]-phenyl}-methanol → 4-[5-(2-Chlorobiphenyl-4-yl)-[1,2,4]-oxadiazol-3-yl]-benzaldehyde

HRID 1777369ノート

反応式

HRID 1777369 の反応式
[Cr](Cl)([O-])(=O)=O.[NH+]1C=CC=CC=1.[Cl:12][C:13]1[CH:18]=[C:17]([C:19]2[O:23][N:22]=[C:21]([C:24]3[CH:29]=[CH:28][C:27]([CH2:30][OH:31])=[CH:26][CH:25]=3)[N:20]=2)[CH:16]=[CH:15][C:14]=1[C:32]1[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=1>ClCCl>[Cl:12][C:13]1[CH:18]=[C:17]([C:19]2[O:23][N:22]=[C:21]([C:24]3[CH:29]=[CH:28][C:27]([CH:30]=[O:31])=[CH:26][CH:25]=3)[N:20]=2)[CH:16]=[CH:15][C:14]=1[C:32]1[CH:33]=[CH:34][CH:35]=[CH:36][CH:37]=1

参加物

4

反応物 2

HCID 70869544{4-[5-(2-Chlorobiphenyl-4-yl)-[1,2,4]-oxadiazol-3-yl]-phenyl}-methanolHCID 178418287HCID 178418287、化合物

生成物 1

HCID 867151454-[5-(2-Chlorobiphenyl-4-yl)-[1,2,4]-oxadiazol-3-yl]-benzaldehyde

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

Pyridiniumchlorochromate (3.6 g, 0.017 mol) is added to a solution of {4-[5-(2-chlorobiphenyl-4-yl)-[1,2,4]-oxadiazol-3-yl]-phenyl}-methanol (4.0 g, 0.011 mol) in dichloromethane (40 mL). The reaction mixture is stirred at room temperature for 30 minutes, filtered and washed with dichloromethane (40 mL). Filtrate is concentrated under reduced pressure to give crude which is purified by column chromatography (230; 400 mesh: 9.5:0.5 toluene:ethyl acetate) to yield 4-[5-(2-chlorobiphenyl-4-yl)-[1,2,4]-oxadiazol-3-yl]-benzaldehyde.

後処理

  1. filtrationfiltered
  2. washwashed with dichloromethane (40 mL)
  3. concentrationFiltrate is concentrated under reduced pressure
  4. customto give crude which
  5. customis purified by column chromatography (230; 400 mesh: 9.5:0.5 toluene:ethyl acetate)

出典と根拠

ORDレコード
ord-d7a052f0dc084490a71bb912ab50e8a8
出典データセット
uspto-grants-2016_02
特許番号
US09266867B2

反応ノート

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