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Acetic Anhydride → N-(1-Acetyl-1H-benzotriazol-5-yl)-acetamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Acetic Anhydride | HCID 7918 | — |
| 反応物 | Ninhydrin | HCID 10236 | — |
| 反応物 | HCID 178507366 | HCID 178507366 | — |
| 生成物 | N-(1-Acetyl-1H-benzotriazol-5-yl)-acetamide | HCID 59344501 | — |
反応手順
A solution of 5-amino-1H-benzotriazole (1.07 g, 8 mmol) in acetic anhydride (50 ml, excess) was stirred at 90° C. for two hours, by which time TLC (A) and ninhydrin development indicated conversion of starting materials. Excess acetic anhydride and acetic acid were removed in vacuo to afford [18] as an off white solid. Rf (A) 0.48; m/z (FAB) 219.08632 [(M+H)+ calc. for C10H11N4O2 219.08820].
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07741102B2 |
| 出典データセット | uspto-grants-2010_06 |
| ORD ID | ord-f9011c19101a490c8fd24c8be60a3ab0 |
| 出典メモ | uspto-grants-2010_06 |