Triphenylphosphine → 2-(5,6-Dichloro-1H-indol-3-yl)ethanamine

HRID 1777555ノート

反応式

HRID 1777555 の反応式
[N:1]([CH2:4][CH2:5][C:6]1[C:14]2[C:9](=[CH:10][C:11]([Cl:16])=[C:12]([Cl:15])[CH:13]=2)[NH:8][C:7]=1[Si](CC)(CC)CC)=[N+]=[N-].C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1>CO>[Cl:15][C:12]1[CH:13]=[C:14]2[C:9](=[CH:10][C:11]=1[Cl:16])[NH:8][CH:7]=[C:6]2[CH2:5][CH2:4][NH2:1]

参加物

4

反応物 2

HCID 11776TriphenylphosphineHCID 866993923-(2-Azidoethyl)-5,6-dichloro-2-(triethylsilyl)-1H-indole

生成物 1

HCID 133016902-(5,6-Dichloro-1H-indol-3-yl)ethanamine

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

反応条件

温度
70 °C

実験手順

A mixture of 3-(2-azidoethyl)-5,6-dichloro-2-(triethylsilyl)-1H-indole (0.497 g; 1.35 mmol) and triphenylphosphine (0.529 g; 1.35 mmol) in methanol (10 mL) was stirred at 70° C. for 2 hours. The reaction mixture was concentrated under reduced pressure and the crude material was dissolved in a solution of tetrabutylamonium fluoride (4.04 mL 1M) in THF, stirred at room temperature for 36 hours, and concentrated under reduced pressure. The crude material was used without any further purification.

後処理

  1. concentrationThe reaction mixture was concentrated under reduced pressure
  2. dissolutionthe crude material was dissolved in a solution of tetrabutylamonium fluoride (4.04 mL 1M) in THF
  3. stirringstirred at room temperature for 36 hours
  4. concentrationconcentrated under reduced pressure
  5. customThe crude material was used without any further purification

出典と根拠

ORDレコード
ord-518fca3dfc114fe29036d55eddec0411
出典データセット
uspto-grants-2016_02
特許番号
US09266832B2

反応ノート

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