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Benzyl Alcohol → benzyl 2-(3,5-dimethyl-1H-pyrazol-1-yl)acetate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Benzyl Alcohol | HCID 244 | — |
| 反応物 | Dicyclohexylcarbodiimide | HCID 10868 | — |
| 反応物 | (3,5-Dimethyl-1H-pyrazol-1-yl)acetic acid | HCID 572875 | — |
| 触媒 | 4-(Dimethylamino)pyridine | HCID 14284 | — |
| 溶媒 | Acetonitrile | HCID 6342 | — |
| 生成物 | benzyl 2-(3,5-dimethyl-1H-pyrazol-1-yl)acetate | HCID 52463841 | — |
反応手順
A mixture of (3,5-dimethyl-1H-pyrazol-1-yl)acetic acid (600 mg), benzyl alcohol (0.402 mL), DMAP (194 mg) and DCC (802 mg) in MeCN (40 mL) was stirred at RT overnight. The suspension was filtered off and the resulting solution was evaporated to dryness. The residue was purified by CC (Hept/EA 7/3) to afford benzyl 2-(3,5-dimethyl-1H-pyrazol-1-yl)acetate (460 mg, white solid). LC-MS (B): tR=0.80 min; [M+H]+: 245.18.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US09266876B2 |
| 出典データセット | uspto-grants-2016_02 |
| ORD ID | ord-bd5d153c9de04fad9880e8f06258083d |
| 出典メモ | uspto-grants-2016_02 |