3-(Dimethylamino)-2,2-dimethyl-1-propanol → 6-Amino-4-(3-(dimethylamino)-2,2-dimethylpropoxy)nicotinonitrile

HRID 1777925

反応式

HRID 1777925 の反応式
[NH2:1][C:2]1[CH:9]=[C:8](F)[C:5]([C:6]#[N:7])=[CH:4][N:3]=1.[CH3:11][N:12]([CH3:19])[CH2:13][C:14]([CH3:18])([CH3:17])[CH2:15][OH:16]>>[NH2:1][C:2]1[CH:9]=[C:8]([O:16][CH2:15][C:14]([CH3:18])([CH3:17])[CH2:13][N:12]([CH3:19])[CH3:11])[C:5]([C:6]#[N:7])=[CH:4][N:3]=1

参加物

3

反応物 2

HCID 879193-(Dimethylamino)-2,2-dimethyl-1-propanolHCID 1180369016-Amino-4-fluoronicotinonitrile

生成物 1

HCID 1180361916-Amino-4-(3-(dimethylamino)-2,2-dimethylpropoxy)nicotinonitrile

実験手順

From intermediate 21 and 3-(dimethylamino)-2,2-dimethylpropan-1-ol, reacted in an analogous manner to the preparation of intermediate 68. UPLC-MS 3: Rt=0.40 min; MS m/z [M+H]+ 249.2.

出典と根拠

ORDレコード
ord-f937083692d04dd7bd1b7b71fd1a4739
出典データセット
uspto-grants-2016_02
特許番号
US09266883B2

関連ノート

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