2-Thiophenemethanol → 6-Amino-4-(thiophen-2-ylmethoxy)nicotinonitrile

反応式

[NH2:1][C:2]1[CH:9]=[C:8](F)[C:5]([C:6]#[N:7])=[CH:4][N:3]=1.[S:11]1[CH:15]=[CH:14][CH:13]=[C:12]1[CH2:16][OH:17].NC1C=C(OC(C)C)C(C#N)=CN=1>>[NH2:1][C:2]1[CH:9]=[C:8]([O:17][CH2:16][C:12]2[S:11][CH:15]=[CH:14][CH:13]=2)[C:5]([C:6]#[N:7])=[CH:4][N:3]=1

参加物

反応物 3

HCID 694672-Thiophenemethanol

HCID 1180369016-Amino-4-fluoronicotinonitrile

HCID 1180369706-Amino-4-isopropoxynicotinonitrile

生成物 1

HCID 1180368296-Amino-4-(thiophen-2-ylmethoxy)nicotinonitrile

実験手順

From intermediate 21 and thiophen-2-ylmethanol, synthesised in an analogous manner to intermediate 97, the title compound was obtained as a pale-yellow solid. (UPLC-MS 3) tR 0.75; ESI-MS 232.1 [M+H]+.

出典と根拠

ORDレコード: ord-b4bef3b6aff9428bb2cc26e8117e9719
出典データセット: uspto-grants-2016_02
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US09266883B2

反応ノート

読み込み中…